The coenzyme every cell uses for energy.^*

NAD+ is the molecular substrate your cells use to produce energy and repair DNA. Levels drop with age. Restoring them changes how you feel.

Longevity

NAD+

Nicotinamide adenine dinucleotide

Tides · Clinician-Prescribed

What it is

A coenzyme (nicotinamide adenine dinucleotide) present in every cell of the body, central to converting food into usable energy and to DNA repair.

Primary benefit

Daytime energy that holds without stimulant dependence, plus mental clarity and sleep quality improvements over 4-8 weeks.

Mechanism

Restores depleted NAD+ pools in mitochondria and activates sirtuins — proteins that regulate cellular repair, metabolism, and aging.

Who it's for

Adults 35+ experiencing mid-day energy crashes, anyone in long-term recovery, and the longevity-focused crowd treating cellular aging as a tractable target.

Read the full science

What Tides prescribesNAD+Direct cellular delivery. Clinician-dosed. Therapeutic concentration.

What's sold as OTC NAD supportOral NAD precursors (NR, NMN)Partial absorption. Conversion-dependent. Plateaus at therapeutic doses.

What it does

Sustained energy
Mitochondrial-level fuel, not stimulant lift. Patients commonly describe it as the energy they had a decade ago, returning slowly across the first month.
DNA repair pathways
NAD+ is the substrate sirtuins and PARP enzymes need to do their work. Both run downstream of nearly every longevity intervention. Restoring NAD+ restores the upstream limit.
Mental clarity
Mitochondrial density in the brain is high. When the substrate is back, so is the clarity many adults attribute to aging but is actually substrate depletion.
The first compound most patients feel
Of every protocol on the menu, NAD+ has the highest first-month subjective response rate. It is often the foundation patients build a longer protocol around.

How it works

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to mitochondrial energy production and the sirtuin family of longevity enzymes. Endogenous levels decline roughly 50% by age 50, and oral precursor supplements struggle to move blood levels meaningfully. Direct injection bypasses the absorption ceiling and restores the substrate the cell needs to do its actual work.